Centennial longevity is based largely on the internal physiological functioning and health inputs and outcomes of these individuals. Physiological functioning, including immune system functioning, was maintained and even increased in these long-lived humans. Neutrophil function to fight infections and glutathione and catalyst activity are also maintained over the years. These results show high correlations between the levels of centenarians and those of young adults. Genetically, the longer the telomere, the longer the lifespan, due to cell division. Polymorphic genes regulate the immune system and other surrounding structures, maintaining their functions. Additionally, health-conscious individuals are more likely to maintain a longer life and reach the age of a century. This is due to maintaining functioning by adapting healthy routines throughout life, even into old age. In conclusion, the maintenance of the organism and physiological aspects similar to those of young adults in advanced age show a great increase in survival and life beyond 100 years. Keywords: Centenarians, physiology, immune system, nutrition, genetics, longevityI centenarians are currently at the peak of longevity in the history of human life. Over the centuries, the centenarian population around the world has increased significantly. In the United States, there are currently 22 centenarians per 100,000 U.S. citizens, and the number is increasing (Hausman, 2011, p. 203-209). By 2050 there will be approximately 3.2 million centenarians worldwide (Hausman, 2011, p. 203-209). As numbers increase, how can this be achieved? Research and studies try to find universal answers in the physiological, genetic and he......middle of paper......une system in extreme longevity. Experimental Gerontology, 43(2), 61-65.Stathakos, D. (2005). Greek centenarians: assessment of functional health status and lifestyle characteristics. Experimental Gerontology, 40(6), 512-518. Terry, D. (2008). Association of longer telomeres with better health in centenarians. The Journals of Gerontology.Series A, Biological Sciences and Medical Sciences, 63(8), 809-812.Toft, A.D. (1994). If I were to live to be a hundred. . . The Lancet, 343, 434. Willcox, DC rai g. (2008). Life at the Extreme Edge: Phenotypic Characteristics of Supercentenarians in Okinawa. Gerontology diaries. Series A, Biological Sciences and Medical Sciences, 63(11), 1201-1208.Wojda, A. (2007). Effects of age and sex on the frequencies of non-disjunction of micronuclei and chromosomes in centenarians and younger subjects. Mutagenesis, 22(3), 195-200.