How has the revolution in DNA technologies changed our understanding of medicine and disease?Introduction;When Watson and Crick discovered the double helix structure of DNA in 1953, they claimed to having ensured the discovery as “finding the secret of life”. Yet, as in all scientific activities, the news does not stop here. 60 years later, a team led by chemist “Shankar Balasubramanian” and oncologist biologist “Steve Jackson” found an unusual four-stranded arrangement of DNA, known as G-quadruplexes occurring within telomeres, these G-quadruplexes which have been shown to have an affinity for genes that have a role in controlling cell proliferation (these could play a role in treating tumors by stopping their proliferation with future research) (http: //www.cam.ac.uk /research/news/a-new-dimension-to-dna-and-personalised-medicine-of-the-future#sthash.Kzyo4IZP.dpuf) Knowledge of the human genome has been growing exponentially, in parallel it has expanded in recent 10-15 years also the knowledge of the "Epigenome", with the result that we know even less than we imagined. The implications are piling higher and higher, and more data is compiled every day than we know what to do with or how to analyze in a coherent way. We will have a future of individualized medicine, gene-targeted therapies, capable of turning off and on any gene of interest via DNA hypermethylation or hypomethylation, histone modification, RNAi and chromatin remodeling; Having the ability to target overexpression or lack of it, with gene-targeted therapies, would allow us to cure the disease even before it appears, there are studies around the world on newborns whose genome is mapped to look for the disease , a single basis change can silence or overexpress t...... central part of the article ......logy for disease control: past, present and future david Weatherall, Brian Greenwood, Heng Leng Chee and Prawase Wasi4. Integrating large-scale genomic information into clinical practice, Steve Olson, Sarah H. Beachy, Claire F. Giammaria, andadam c. Berger, speakers, 2012; iso; 978-0-309-22034-7)5. http://www.lifetechnologies.com/au/en/home/life-science/sequencing/next-generation-sequencing/ion-torrent-next-generation-sequencing-applications.html)6. Science. 2014 March 21;343 (6177):1360-3. doi: 10.1126/science.1250212. Epub 2014 Feb 27. Highly multiplexed subcellular RNA sequencing in situ. Lee JH1, Daugharthy ER, Scheiman J, Kalhor R, Yang JL, Ferrante TC, Terry R, ​​Jeanty SS, Li C, Amamoto R, Peters DT, Turczyk BM, Marblestone AH, Inverso SA, Bernard A, Mali P, Rios X , Aach J, Church GM.7. http://www.wired.com/2014/05/synthetic-dna-cells/?mbid=social_fb