The Tuskegee Syphilis Study was an unethical prospective study based on differences between white and black males that began in the 1930s. This study involved the mistreatment of black males and their families in an experimental study of the effects of untreated syphilis. With very little knowledge of the study or the disease on the part of the participants, the Tuskegee Syphilis Study can be seen as one of the worst forms of injustice in US history. Although it could be argued that the study was originally intended for good use, the Tuskegee Syphilis Study was unethical and racist because only poor, uneducated black males were used in the experiment, participants were not adequately informed of their participation in the experiment, and participants were denied any type of treatment. This article aims to explain how the African American males used in this study were systematically singled out for exploitation based on race and socioeconomic factors. Living in the 1930s was difficult for many African Americans. The Great Depression was evident as many African Americans were hired as sharecroppers in the cotton crops to work the land of white landowners. Most of these sharecroppers had little or no formal education. Conditions were horrific as many of these families had no running water, electricity or medical care. During this period African Americans had higher mortality and morbidity rates than whites. Many believed it would be a waste to provide blacks with more medical care during a time when many resources were scarce. Some members of the US Public Health Service disagreed and wanted to demonstrate that blacks also needed more health care and that government-funded services were just as…half of paper…Nature”: The Tuskegee Experiments and the Plantation of the New South." Journal of Medical Humanities 30.3 (2009): 155-171. Academic research completed. Web. 20 November 2011.Sharma, Alankaar. “Sick Race, Racialized Sickness: The Story of the American Social Hygiene Association's Negro Project Against the Background of the Tuskegee Syphilis Experiment.” Journal of African American Studies 14.2 (2010): 247-262. Academic research completed. Web. November 20, 2011. Thomas, S. B., and S. C. Quinn. “The Tuskegee Syphilis Study, 1932 to 1972: Implications for HIV Education and AIDS Risk Education Programs in the Black Community.” American Journal of Public Health 81.11 (1991): 1498-505. Academic research completed. Web.Walker, Charles A. “Lest We Forget: The Tuskegee Experiment.” The Journal of Theory Construction. and Test 13.1 (2009): 5-6. Academic research completed. Network. November 11. 2011.